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PCR primer design is designing a set of nucletides, usually 20 or so bases to be complimentary to your sequence at a given location. Then design another primer on the "reverse" strand of DNA at a different location. When you do PCR the two primers will combine with the dNTPs you put in an generate double stranded DNA in between the two primer sets. This is very useful for amplifying genes out of plasmids, creating DNA mutations or for genotyping animals.